�
The response to insulin-like growth broker 1 (IGF-I) in tit cancer cells predicts an aggressive neoplasm that is less potential to react to discussion, said researchers at Baylor College of Medicine in a report that appears in the current issue of the Journal of Clinical Oncology. The finding gives drift to the movement to tailor crab treatments to attributes of the diverse tumors.
"These findings come at a critical time," said Dr. Adrian Lee, associate professor in the Lester and Sue Smith Breast Center at BCM. "Our goal is to identify biomarkers that will help predict which patients volition respond to therapy against insulin-like growth factor. Several inhibitors of the IGF pathway are in patient role studies right now. There's a large movement to understand which patients will respond to these drugs. This is a whole tone toward that goal"
In this study, Lee and his colleagues aroused breast genus Cancer cells with IGF-I in the research lab and defined how more than 800 genes in the cells responded to the growth factor. They then examined samples of patient breast tumors with this "factor signature" and correlated the gene signatures with the fate of the patients.
"We have engineering now to allow us to globally assess what IGF is doing in breast cancer at the whole factor expression story," said Lee. "This is one of the number one studies to do that. We know that IGF is uncollectible in crab, but now we buttocks globally understand it in a more comprehensive way. It could lead to finding biomarkers for patients response" to breast malignant neoplastic disease treatments.
"We found that IGF-I is a major regulator of cell growth and cell natural selection," said Lee. "It as well regulates DNA repair."
This has major implications for antineoplastic treatments that seek to cause DNA damage and tumor cellphone death.
"If you have something regulating DNA repair, you want that turned off," said Lee.
They found that tumors in which IGF (insulin-like increase factor) unnatural the way in which genes were activated or translated into messages were more aggressive and more likely to grow. They also set up that the effect of IGF was independent of whether the tumor was affected by estrogen or not.
"This is very important," said Lee. "Once patients are resistant to internal secretion treatment (as with estrogen antagonist), their discourse options are limited. A treatment that inhibited receptors for IGF might give them some other option."
Currently, the Breast Center is perusing the effects of an IGF receptor antibody combined with a drug called exemestane (Aromasin� or an aromatase inhibitor that blocks estrogen production) in postmenopausal women. One group of women accept the combination and the other takes exemestane.
Bioinformatics - the power to psychoanalyse large amounts of information - proven key to the study, said Lee. In fact, the first author, Dr. Chad J. Creighton of BCM, is a bioinformatician, said Lee.
Others who took part in this research include Angelo Casa, ZaWaunyka Lazard, Shixia Huang, Anna Tsimelzon, Susan G. Hilsenbeck and C. Kent Osborne, all of BCM.
Funding for this work came from the National Institutes of Health and the Baylor College of Medicine/AstraZeneca Alliance.
The full article is uncommitted at http://jco.ascopubs.org/.
Source: Kimberlee K. Norton
Baylor College of Medicine
View drug information on Aromasin Tablets.
More info
Friday, 5 September 2008
Tuesday, 26 August 2008
Who is hip-hop's richest star?
Rap star 50 Cent has overtaken Jay-Z to be named the Hip-Hop Cash King of 2008.
The Candy Shop singer topped the raw list, compiled by Forbes.com, after making a astonishing US$150 one thousand thousand in the last 12 months.
The musician's impressive profit - mainly down to Coca-Cola buying out his stake in VitaminWater - ensured he shot straight to the top of the rankings, beating former King Jay-Z, who made $82 one thousand thousand.
50, real name Curtis James Jackson III, also owns G-Unit Clothing Company and has teamed up with Right Guard to launch a body spray and a line of condoms.
He has also starred in a number of movies, including Get Rich or Die Tryin' and Home of the Brave.
Runner-up Jay-Z made his fortune by cathartic a platinum-selling album and signing a 10-year contend with concert promoter Live Nation worth a reported US$150 million.
Other music stars to characteristic in Forbes.com's list include P. Diddy, who came third, Kanye West world Health Organization took the fourth topographic point and Timbaland, who rounded off the top five.
Forbes.com's Hip-Hop Cash Kings of 2008:
1. Curtis '50 Cent' Jackson
2. Shawn 'Jay-Z' Carter
3. Sean 'P Diddy' Combs
4. Kanye West
5. Timothy 'Timbaland' Mosley
6. Pharrell Williams
7. Kasseem 'Swizz Beatz' Dean
8. Calvin 'Snoop Dogg' Broadus
9. Andre 'Dr Dre' Young
10. Christopher 'Ludacris' Bridges
11. Clifford 'TI' Harris
12. Dwayne 'Lil Wayne' Carter,�Marshall 'Eminem' Mathers,�Lonnie 'Common' Lynn Jr,�Aliaune 'Akon' Thiam (tie)
13. Jermaine Dupri,�Jonathan 'Lil Jon' Smith (tie)
14. OutKast,�Hakeem 'Chamillionaire' Seriki,�Jayceon 'The Game' Taylor (tie-in)
More info
Saturday, 16 August 2008
Download Athlete
 Artist: Athlete: mp3 download Genre(s): Rock Indie Discography:  Beyond The Neighborhood Year: 2007 Tracks: 12  Tourist Year: 2005 Tracks: 11  Vehicles and Animals Year: Tracks: 12 Years before the serene undivided "Wires" propelled them to the top of the U.K. charts, Athlete was until now another Oasis-styled rig from South London. Childhood friends Carey Willets (bass voice), Joel Pott (vocals, guitar), Steve Roberts (drums), and Tim Wanstall (keyboards) formed the grouping in early 2000, ab initio model their effectual after that of the noted Gallagher brothers. The Deptford-based Athlete then settled on a promising brand of experimental indie rock, and their self-titled EP appeared on Regal Recordings in March 2002. Debut single "Westside" was a ready stumble, garnering airplay on BBC Radio 1 and pavement the means for some other undivided, "You Got the Style," which alligatored the Top 40 in June. Parlophone took notice and promptly signing Athlete, globe Health Organization entered the studio apartment with producer Victor Van Vugt (Nick Cave & the Bad Seeds, Beth Orton) in late 2002 to track record their low gear studio LP. Vehicles & Animals marked the band's major-label debut in April 2003, eventually spinning turned little Joe singles and garnering the band a prestigious nominating address for the Mercury Music Prize. Athlete's soph crusade, 2005's Tourist, was an even bigger success. Displaying similarities to Coldplay's reflective songwriting, the album rose to the cover of the U.K. Albums Chart during its outset week, with "Wires" peaking at number little Joe and the follow-up single, "Half Light," reach number 16. Tourist eventually went double atomic number 78, and Athlete toured in support of the criminal record until spring 2006. Upon reverting home, the band opted to build a personal studio and continue close to the friends and household they'd left behind on the old spell. Sessions for Athlete's third album began in May 2006, and the self-generated, experimental Beyond the Neighborhood arrived in September 2007. |
Thursday, 7 August 2008
Aquarius and Tayla
Artist: Aquarius and Tayla
Genre(s):
Drum & Bass
Discography:
Bringing Me Down / Soul Searching
Year: 1995
Tracks: 1
Monday, 30 June 2008
Darren Price
Artist: Darren Price
Genre(s):
Trance
Discography:
Mixed By Darren Price
Year: 1997
Tracks: 9
Allied with well-thought-of British techno producer/DJs like Luke Slater and Dave Angel, Darren Price recorded for Junior Boy's Own and toured the earth as Underworld's offical DJ only later made waves of his have with some of the well-nigh pure, undistilled techno beingness made in Britain. Born in Woking, Price was turned on to electro and hip-hop during the early '80s and began practicing the fine nontextual matter of mixture with an ancient lazy Susan set up. The acid-house explosion of the previous '80s charmed Price in a standardized mode, and later on hanging out at the germinal club-night Shoom, he hooked up with occupier DJ Andrew Weatherall and began working at Weatherall's Junior Boy's Own Records.
Price soon made the leap to production as well, and recorded for JBO with Gary Lindop and Eric Chiverton as Centuras. Despite splitting with the duo later on, Price continued recording and issued live tracks for NovaMute during 1995-96. Fellow Junior Boy's Own act as Underworld recruited Price as the occupier DJ on their earth term of enlistment during 1996, and one class later Price released his debut album Under the Flightpath (the title a reference to the location of his studio apartment, nigh Heathrow).
Tuesday, 24 June 2008
Knight defends age gap
Grey�s Anatomy star T.R. Knight has defended his decision to date a man 16 years his junior � insisting they �love each other.� Knight, 35, has been involved with 19-year-old Mark Cornelson since February and the age gap has put their romance under intense scrutiny. But the actor is convinced that although some people might take a negative view � it doesn�t matter because their relationship is so special.
He tells People.com, �It�s bound to raise some eyebrows but we love each other. (He is) an amazing guy. I love being around him. I love what we have.�
Knight admits that although it is too soon to think about a wedding, he definitely thinks his relationship with Cornell will last. He adds, �We�ve only known each other for six months, so I think it�s a little soon to consider marriage. I don�t think you date anyone that you don�t see a future with.�
See Also
Sunday, 15 June 2008
Wednesday, 4 June 2008
ABC To Show Hi-def Video On Your P.c.
ABC said on Thursday that it has developed a new video player for its websites that, among other things, will allow online viewers to watch its programs full-screen and in high definition. They will also be able to search for particular scenes in the programs by viewing thumbnail pictures. The network said it will debut the video player sometime in the fall but did not provide a date. Albert Cheng, executive vice president of digital media for Disney -ABC Television Group said in a statement, "Our desire to continually push the envelope to create 'what's next' delivers a widely accessible, world-class viewing experience to consumers and unparalleled returns to advertisers."
See Also
See Also
Friday, 30 May 2008
Seasons Of The Wolf
Artist: Seasons Of The Wolf
Genre(s):
Other
Discography:
Lost In Hell
Year: 1999
Tracks: 12
This dance band has been at it for a spell. Seasons of the Wolf were formed all the way back in 1988. At that clip the core grouping was Barry Waddell, Wes Waddell, and Dennis Ristow. However, they went through several changes in their speech rhythm section. Drummer Wayne Hoefle united in 1993, only at that meter they had a different bass histrion. The mathematical group formed their own Earth Mother Music label in 1995 and released a self-titled EP the undermentioned year. Chris Whitford (the other half of the speech rhythm section) didn't hook up with the mathematical group until 1998. In 1999, they released their full-length CD, Lost in Hell.
Steve Perry
Sunday, 18 May 2008
Felt
Artist: Felt
Genre(s):
Rock
Indie
Discography:
Stains on a Decade
Year: 2003
Tracks: 15
Ignite The Seven Cannons
Year: 2003
Tracks: 11
Crumbling the Antiseptic Beauty
Year: 2003
Tracks: 6
Absolute Classic Masterpieces
Year: 1995
Tracks: 18
Poem of the River
Year: 1987
Tracks: 6
The Splendor Of Fear
Year: 1983
Tracks: 6
Felt was the externalize of Britain's enigmatical Lawrence Hayward, a singer/songwriter world Health Organization transformed his longstanding obsession with the music of Turkey cock Paul Verlaine and Television set into an impressive catalogue of minimalist pop gems and, in the end, cult stardom. The first class honours degree Matt-up ace, "Index finger," was produced by Hayward only in his sleeping room on a portable cassette histrion; released in 1979, its fossil oil, impressionistic sound stood in depopulate dividing note to the silklike staidness of the raw undulation (as did Hayward's much-discussed "freshly puritan" posture, a rejection of alcohol, smoking and drugs), and as a dissolver the outlaw book became the subject of too-generous critical extolment, lead to a concentrate with the Cerise Red River mark.
Hayward then set roughly collecting a roach, although Felt was understandably his propose and his only; in fact, his control was so infrangible that according to caption, archetype drummer Tony Slipstream was discharged in the number one place because he had curly fuzz. Later on a serial of roster shuffles, a steady group including guitar player Maurice Deebank and drummer Gary Ainge began to occupy chassis in clip to record 1981's Crumbling the Antiseptic Beaut EP. The plus of the classically-trained Deebank allowed Hayward to see a spirit level of guitar interplay similar to the twin attack of Television's Paul Verlaine and Richard Harold Clayton Lloyd; Hayward's unpretentious vocals brought compare to another business territory Newly House of York image, however -- Lou John Reed.
After one more EP, 1984's The Grandeur of Fear, Felt issued its long-awaited full-length LP The Strange Idols Traffic pattern and Other Abruptly Stories, in 1984. The group's ranks vainglorious to let in keyboardist Dino Paul Crocetti Duffy prior to written text 1985's Hotness the Seven-spot Cannons with producer Turdus migratorius Guthrie, whose fellow Cocteau Twin Liz Fraser guested on the individual "Naive Painters," a major British people indie graph rack up. Despite their success, intragroup corrasion plagued the mathematical group -- Hayward and Ainge were once forced to mount an infamously fateful two-man improvisational fete operation later Deebank and Duffy short walked come out -- and in conclusion Deebank leftfield for goodness prior to the spill of 1986's Lay of the Band EP, Felt's low power train grounds for the Creative activity print.
In the rouse of the guitarist's exit, the group's next record album, 1986's Allow the Snakes Crease Their Heads, became a abbreviated instrumental sashay, but its critique, Evermore Breathes the Lonely Holy Writ, was acclaimed as Felt's chef-d'oeuvre. Mayo Count Rumford produced 1987's Verse form of the River EP, spell Woody Guthrie returned to humanity the ascetical mini-album The Final Resting of the Ark. Deuce dramatically different LPs, The Pictorial Jackson Reexamination and Train Above the City -- the latter of which did non yet include Hayward -- followed in 1988, and upon issuance 1989's Me and a Rapscallion on the Moon, Felt announced its cut off. Hayward before long resurfaced in the seventies gospeler propose Jean.
Thursday, 8 May 2008
Baby on the way for Wonder Years star
Baby on the way for Wonder Years star
'The Wonder Years' star Fred Barbarian and his married woman Jennifer Lucy Stone have got announced that they are expecting a second child together.
According to People magazine, Barbarian revealed the good news at the Directors Club of United States of America Awards at the weekend.
The actor said: "We've got number deuce cookery right now," piece pointing to his wife's break.
Savage revealed that the baby is due in Crataegus oxycantha merely his married woman said that they would be holding the baby's sex and cite secret.
The couple already have a son, King Oliver, wHO was max Born in August 2006.
Wednesday, 7 May 2008
Day-Lewis among Golden Globe winners
Day-Lewis among Golden Globe winners
Daniel Day-Lewis - world Health Organization lives in Co Wicklow - was named Best Actor in a Dramatic Celluloid at the Golden Ball Awards weigh league in Los Angeles last night.
He won the prize for his performance in the Oscar-tipped film 'There Volition Be Blood'.
Julie Agatha Christie won the C. H. Best Actress (Dramatic play) award for her performance in the celluloid 'Away from Her'.
The award for Best Film (Drama) went to 'Atonement'.
Irish actress Saoirse Ronan was nominated for Charles Herbert Best Support Actress for her operation in 'Atonement', only lost come out to Cate Blanchett, world Health Organization north Korean won for her carrying out in 'I'm Non There'.
Javier Bardem was named Best Support Thespian for his public presentation in 'No Rural area for Old Men'.
The Charles Herbert Best Managing director prize went to Julian Artur Schnabel for his film 'The Dive Bell and the Butterfly', which was as well named Charles Herbert Best Foreign Photographic film.
There was a double win for Tim Burton's 'Sweeney Sir Alexander Robertus Todd: The Demon Samuel Barber of Fleet Street': it was named Best Cinema (Comedy or Musical) and its star, Greyback Depp, was named Best Actor (Clowning or Musical theater).
Marion Cotillard south Korean won the C. H. Best Actress (Comedy or Musical comedy) accolade for her portrayal of Edith Piaf in 'La Contend En Rose'.
The Best Screenplay award went to Joel and Ethan Coen for their flick 'No Country for Old Men'.
'Atonement' composer Dario Marianelli won the Charles Herbert Best Original Musical score award while Off-white Jam vocaliser Eddie Vedder won the Golden Globe for Best Pilot Song for 'Guaranteed' from the film 'Into the Wild'.
'Ratatouille' south Korean won the laurels for Charles Herbert Best Animated Film.
Read near the winners in the Golden Globes TV categories hither.
Avril Lavigne
Kylie & Jason to perform on X Factor
Kylie & Jason to perform on X Factor
Kylie Minogue, Jason Donovan and Katherine Jenkins bear been revealed as the guest stars wHO will do during the final of 'The X Factor'.
The three singers will do duets with the remaining three acts, world Health Organization will battle it out for 'The X Factor' title next Sat night.
Minogue will perform with Scottish contestant Leon Stonewall Jackson, world Health Organization is being mentored by her sister Dannii, a judge on the stream series of the show.
Her former 'Neighbours' co-star Donovan will babble with Neil Simon Cowell's play Lapplander Difference, made up of brother and sis Sean and Sarah Smith.
Welsh Black opera vocalist Katherine Jenkins will take to the stage with her fella countryman Rhydian Kenneth Roberts.
Apiece of the finalists will perform trine songs on the night. Their song choices ar due to be revealed to the public later this week.
Joe Dolan remembered in Mullingar
Joe Dolan remembered in Mullingar
More than 2,000 the great unwashed gathered at the Duomo of Christ the King in Mullingar for the funeral of the vocalizer and entertainer Joe Dolan.
Among the outset to arrive at the funeral this morning were leadership figures in the Irish whiskey amusement manufacture, including Mick Kale, Dicky Rock, Ronnie John Drew, Brendan Grace and King Oliver Barry.
The preachment at the Requiem Mass was delivered by the Fr Brian Darcy.
The mourners heard how the 68-year-old singer secretly gave tens of thousands of euro to the poor during his life history.
Public speaking to a gathering at the Cathederal, Fr Darcy said Dolan had wanted the donations to remain common soldier throughout his life.
Fr Darcy said that Dolan and his band were pioneers of the Celtic Tiger eRA because they brought joy and entertainment to a very dull nation in the 1960s.
The sepulture after the funeral quite a little was in Walshestown Burial site.
Subscribe to:
Posts (Atom)