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The response to insulin-like growth broker 1 (IGF-I) in tit cancer cells predicts an aggressive neoplasm that is less potential to react to discussion, said researchers at Baylor College of Medicine in a report that appears in the current issue of the Journal of Clinical Oncology. The finding gives drift to the movement to tailor crab treatments to attributes of the diverse tumors.
"These findings come at a critical time," said Dr. Adrian Lee, associate professor in the Lester and Sue Smith Breast Center at BCM. "Our goal is to identify biomarkers that will help predict which patients volition respond to therapy against insulin-like growth factor. Several inhibitors of the IGF pathway are in patient role studies right now. There's a large movement to understand which patients will respond to these drugs. This is a whole tone toward that goal"
In this study, Lee and his colleagues aroused breast genus Cancer cells with IGF-I in the research lab and defined how more than 800 genes in the cells responded to the growth factor. They then examined samples of patient breast tumors with this "factor signature" and correlated the gene signatures with the fate of the patients.
"We have engineering now to allow us to globally assess what IGF is doing in breast cancer at the whole factor expression story," said Lee. "This is one of the number one studies to do that. We know that IGF is uncollectible in crab, but now we buttocks globally understand it in a more comprehensive way. It could lead to finding biomarkers for patients response" to breast malignant neoplastic disease treatments.
"We found that IGF-I is a major regulator of cell growth and cell natural selection," said Lee. "It as well regulates DNA repair."
This has major implications for antineoplastic treatments that seek to cause DNA damage and tumor cellphone death.
"If you have something regulating DNA repair, you want that turned off," said Lee.
They found that tumors in which IGF (insulin-like increase factor) unnatural the way in which genes were activated or translated into messages were more aggressive and more likely to grow. They also set up that the effect of IGF was independent of whether the tumor was affected by estrogen or not.
"This is very important," said Lee. "Once patients are resistant to internal secretion treatment (as with estrogen antagonist), their discourse options are limited. A treatment that inhibited receptors for IGF might give them some other option."
Currently, the Breast Center is perusing the effects of an IGF receptor antibody combined with a drug called exemestane (Aromasin� or an aromatase inhibitor that blocks estrogen production) in postmenopausal women. One group of women accept the combination and the other takes exemestane.
Bioinformatics - the power to psychoanalyse large amounts of information - proven key to the study, said Lee. In fact, the first author, Dr. Chad J. Creighton of BCM, is a bioinformatician, said Lee.
Others who took part in this research include Angelo Casa, ZaWaunyka Lazard, Shixia Huang, Anna Tsimelzon, Susan G. Hilsenbeck and C. Kent Osborne, all of BCM.
Funding for this work came from the National Institutes of Health and the Baylor College of Medicine/AstraZeneca Alliance.
The full article is uncommitted at http://jco.ascopubs.org/.
Source: Kimberlee K. Norton
Baylor College of Medicine
View drug information on Aromasin Tablets.
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Friday 5 September 2008
Tuesday 26 August 2008
Who is hip-hop's richest star?
Rap star 50 Cent has overtaken Jay-Z to be named the Hip-Hop Cash King of 2008.
The Candy Shop singer topped the raw list, compiled by Forbes.com, after making a astonishing US$150 one thousand thousand in the last 12 months.
The musician's impressive profit - mainly down to Coca-Cola buying out his stake in VitaminWater - ensured he shot straight to the top of the rankings, beating former King Jay-Z, who made $82 one thousand thousand.
50, real name Curtis James Jackson III, also owns G-Unit Clothing Company and has teamed up with Right Guard to launch a body spray and a line of condoms.
He has also starred in a number of movies, including Get Rich or Die Tryin' and Home of the Brave.
Runner-up Jay-Z made his fortune by cathartic a platinum-selling album and signing a 10-year contend with concert promoter Live Nation worth a reported US$150 million.
Other music stars to characteristic in Forbes.com's list include P. Diddy, who came third, Kanye West world Health Organization took the fourth topographic point and Timbaland, who rounded off the top five.
Forbes.com's Hip-Hop Cash Kings of 2008:
1. Curtis '50 Cent' Jackson
2. Shawn 'Jay-Z' Carter
3. Sean 'P Diddy' Combs
4. Kanye West
5. Timothy 'Timbaland' Mosley
6. Pharrell Williams
7. Kasseem 'Swizz Beatz' Dean
8. Calvin 'Snoop Dogg' Broadus
9. Andre 'Dr Dre' Young
10. Christopher 'Ludacris' Bridges
11. Clifford 'TI' Harris
12. Dwayne 'Lil Wayne' Carter,�Marshall 'Eminem' Mathers,�Lonnie 'Common' Lynn Jr,�Aliaune 'Akon' Thiam (tie)
13. Jermaine Dupri,�Jonathan 'Lil Jon' Smith (tie)
14. OutKast,�Hakeem 'Chamillionaire' Seriki,�Jayceon 'The Game' Taylor (tie-in)
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Saturday 16 August 2008
Download Athlete
 Artist: Athlete: mp3 download Genre(s): Rock Indie Discography:  Beyond The Neighborhood Year: 2007 Tracks: 12  Tourist Year: 2005 Tracks: 11  Vehicles and Animals Year: Tracks: 12 Years before the serene undivided "Wires" propelled them to the top of the U.K. charts, Athlete was until now another Oasis-styled rig from South London. Childhood friends Carey Willets (bass voice), Joel Pott (vocals, guitar), Steve Roberts (drums), and Tim Wanstall (keyboards) formed the grouping in early 2000, ab initio model their effectual after that of the noted Gallagher brothers. The Deptford-based Athlete then settled on a promising brand of experimental indie rock, and their self-titled EP appeared on Regal Recordings in March 2002. Debut single "Westside" was a ready stumble, garnering airplay on BBC Radio 1 and pavement the means for some other undivided, "You Got the Style," which alligatored the Top 40 in June. Parlophone took notice and promptly signing Athlete, globe Health Organization entered the studio apartment with producer Victor Van Vugt (Nick Cave & the Bad Seeds, Beth Orton) in late 2002 to track record their low gear studio LP. Vehicles & Animals marked the band's major-label debut in April 2003, eventually spinning turned little Joe singles and garnering the band a prestigious nominating address for the Mercury Music Prize. Athlete's soph crusade, 2005's Tourist, was an even bigger success. Displaying similarities to Coldplay's reflective songwriting, the album rose to the cover of the U.K. Albums Chart during its outset week, with "Wires" peaking at number little Joe and the follow-up single, "Half Light," reach number 16. Tourist eventually went double atomic number 78, and Athlete toured in support of the criminal record until spring 2006. Upon reverting home, the band opted to build a personal studio and continue close to the friends and household they'd left behind on the old spell. Sessions for Athlete's third album began in May 2006, and the self-generated, experimental Beyond the Neighborhood arrived in September 2007. |
Thursday 7 August 2008
Aquarius and Tayla
Artist: Aquarius and Tayla
Genre(s):
Drum & Bass
Discography:
Bringing Me Down / Soul Searching
Year: 1995
Tracks: 1
Monday 30 June 2008
Darren Price
Artist: Darren Price
Genre(s):
Trance
Discography:
Mixed By Darren Price
Year: 1997
Tracks: 9
Allied with well-thought-of British techno producer/DJs like Luke Slater and Dave Angel, Darren Price recorded for Junior Boy's Own and toured the earth as Underworld's offical DJ only later made waves of his have with some of the well-nigh pure, undistilled techno beingness made in Britain. Born in Woking, Price was turned on to electro and hip-hop during the early '80s and began practicing the fine nontextual matter of mixture with an ancient lazy Susan set up. The acid-house explosion of the previous '80s charmed Price in a standardized mode, and later on hanging out at the germinal club-night Shoom, he hooked up with occupier DJ Andrew Weatherall and began working at Weatherall's Junior Boy's Own Records.
Price soon made the leap to production as well, and recorded for JBO with Gary Lindop and Eric Chiverton as Centuras. Despite splitting with the duo later on, Price continued recording and issued live tracks for NovaMute during 1995-96. Fellow Junior Boy's Own act as Underworld recruited Price as the occupier DJ on their earth term of enlistment during 1996, and one class later Price released his debut album Under the Flightpath (the title a reference to the location of his studio apartment, nigh Heathrow).
Tuesday 24 June 2008
Knight defends age gap
Grey�s Anatomy star T.R. Knight has defended his decision to date a man 16 years his junior � insisting they �love each other.� Knight, 35, has been involved with 19-year-old Mark Cornelson since February and the age gap has put their romance under intense scrutiny. But the actor is convinced that although some people might take a negative view � it doesn�t matter because their relationship is so special.
He tells People.com, �It�s bound to raise some eyebrows but we love each other. (He is) an amazing guy. I love being around him. I love what we have.�
Knight admits that although it is too soon to think about a wedding, he definitely thinks his relationship with Cornell will last. He adds, �We�ve only known each other for six months, so I think it�s a little soon to consider marriage. I don�t think you date anyone that you don�t see a future with.�
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